Symbol
Name
ID

H2-T23
histocompatibility 2, T region locus 23
MGI:95957

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Eosinophilia

Increased T cell count

Leukopenia

Keratoconjunctivitis sicca

Abnormal lymph node morphology

Lymphadenopathy

Hepatosplenomegaly

Helicobacter pylori infection

Uveitis

Iridocyclitis

Posterior uveitis

Inflammatory abnormality of the eye

Epididymitis

Erythema nodosum

Psoriasiform dermatitis

Maculopapular exanthema

Autoimmunity

Asthma

Disease(s) Associated with HLA-A

pre-eclampsia

Disease(s) Associated with HLA-B

asthma

Behcet's disease

birdshot chorioretinopathy

sarcoidosis

Disease(s) Associated with HLA-C

psoriasis 1

Disease(s) Associated with HLA-G

asthma

Mouse Phenotypes

immune system phenotype

decreased immature NK cell number

decreased mature NK cell number

decreased NK cell number

increased NK cell number

increased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased gamma-delta T cell number

decreased activated T cell number

abnormal CD8-positive, alpha beta T cell morphology

impaired natural killer cell mediated cytotoxicity

abnormal CD4-positive, alpha-beta T cell physiology

abnormal cytotoxic T cell physiology

abnormal T cell activation

abnormal memory T cell physiology

decreased macrophage nitric oxide production

abnormal cytokine level

abnormal immune system physiology

decreased interferon-gamma secretion

decreased susceptibility to autoimmune diabetes

increased susceptibility to experimental autoimmune encephalomyelitis

increased autoantibody level

increased anti-nuclear antigen antibody level

spinal cord inflammation

myositis

abnormal innate immunity

increased susceptibility to bacterial infection

decreased susceptibility to parasitic infection induced morbidity/mortality

increased susceptibility to Herpesvirales infection

increased response to antigen

Availability

Mouse Genotype

H2-D1^b-em1Dvs/H2-D1^b-em1Dvs

H2-D1^b-em2Dvs/H2-D1^b-em2Dvs

H2-D1^b-em3Dvs/H2-D1^b-em3Dvs

H2-D1^b-em4Dvs/H2-D1^b-em4Dvs

H2-D1^bm14/H2-D1^bm14

H2-K1^b-tm1Bpe/H2-K1^b-tm1Bpe

H2-K1^d-em4Dvs/H2-K1^d-em4Dvs

H2-K1^d-em5Dvs/H2-K1^d-em5Dvs

H2-K1^d-em7Dvs/H2-K1^d-em7Dvs

H2-M3^tm1Crw/H2-M3^tm1Crw

H2-Q10^{tm1.1(KOMP)Mbp}/H2-Q10^{tm1.1(KOMP)Mbp}

H2-T23^tm1Cant/H2-T23^tm1Cant

H2-T23^tm3Cant/H2-T23^tm3Cant

Tg(CKMM-tTA)A3Rhvh/0
Tg(tetO-H2-K1)#Papl/0

Tg(H2-L^d)LoxNibl/0

Tg(Camk2a-cre)2Gsc/0
Tg(H2-L^d)LoxNibl/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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